Gotu kola name by Indian Journal of Pharmaceutical sciences “A Potential Herbal Cure-all”.[i] In China, known as gotu kola, it is one of the reported “miracle elixirs of life” known over 2000 years ago.[ii] Gotu kola is the herb for longevity in Thai traditional medicine. It can be used for outside like burn treatment, skin contusion through in diseases like epilepsy, skin diseases, diarrhea, peptic ulcer. It is also benefit for anxiolytic, brain tonic and increase memory.[iii] Gotu kola is certified in Thai national drug list for the benefit and safety.[iv]
Benefit of Gotu kola
- Possess wound healing activity by increasing collagen formation and angiogenesis[v]. increase the tensile strength of the newly formed skin[vi] accelerated wound healing.[vii] [viii] Treatment of photoaging skin, cellulite and striae.[ix] potential use of asiatica extracts as a topical anti-psoriatic agent.[x]
- Act on the connective tissues of the vascular wall, being effective in hypertensive microangiopathy and venous insufficiency and decreasing capillary filtration rate by improving microcirculatory parameters[xi]. In the treatment of scleroderma, it might also assist in stabilizing connective tissue growth, reducing its formation as it reportedly stimulated the formation of hyaluronidase and chondroitin sulfate, as well as exerted a balancing effect on the connective tissue. protecting the integrity of vascular intima.[xii] Treatment of venous insufficiency of the lower limbs.[xiii] improvement of the microcirculation and capillary permeability.[xiv]
Central Nervous system
Sedative and anxiolytic properties:
- stimulatory-nervine tonic, rejuvenant, sedative, tranquilizer and intelligence promoting property[xv] [xvi]
- triterpenes from Centella asiatica had antidepressant activity.[xvii] Significant reduction of the corticosterone level in serum and increase brain serotonin[xviii]
- a potential anticonvulsant as well as antioxidant, and CNS depressant actions.[xix]
Cognitive and antioxidant properties:
- cognitive-enhancing and anti-oxidant properties[xx] . A candidates for a treatment of Alzheimer›s disease that protects neurons from beta-amyloid toxicity.[xxi]
- A dose-dependent reduction of gastric ulceration[xxii] healing gastric ulcers[xxiii]. significantly improved clinical signs of chronic periodontitis .[xxiv]
Antinociceptive and antiinflammatory properties:
- Anti-pain (antinociception) and inflammation[xxv]. The treatment of inflammatory conditions or rheumatism.[xxvi] [xxvii]
- radioprotective properties at a sublethal dose (8 Gy) of Co 60 gamma radiation[xxviii]
- a valuable agent for the therapeutic intervention of human hepatomas.[xxix] Colon cancer [xxx] retarded the development of solid and ascites tumours in mice[xxxi]
- against herpes simplex viruses[xxxii]
Precautions and safety:
- No known toxicity in recommended doses.
- Since high doses of CA can cause sedation, it was warned that individuals should refrain from taking this herb with medications that promote sleep or reduce anxiety. [xxxiii]Theoretically, CA was postulated to interfere with blood glucose levels and thus also possibly interfere with the existing hypoglycaemic therapy and cholesterol lowering agents.[xxxiv]
[xix] Ganachari MS, Babu V, Katare S. Neuropharmacology of an extract derived from Centella asiatica. Pharm Biol. 2004;42:246–52.
[xxv] Somchit MN, Sulaiman MR, Zuraini A, Samsuddin LN, Somchit N, Israf DA, et al. Antinociceptive and antiinflammatory effects ofCentella asiatica. Indian J Pharmacol. 2004;36:377–80.
[xxvi] Newall CA, Anderson LA, Phillipson JD. Hydrocotyle. Herbal Medicines A Guide for Health Care Professionals. London: The Pharmaceutical Press; 1996. pp. 170–72.
[xxxiv] Kartnig T. Clinical applications of Centella asiatica (L) urb. In: Craker LE, Simon JE, editors. Herbs, spices, and medicinal plants: Recent advances in botany, horticulture, and pharmacology.Phoenix AZ: Oryx Press; 1986. pp. 145–73.